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TNF-α and IFN-γ gene variation and genetic susceptibility to type 1 diabetes and its microangiopathic complications
BACKGROUND: TNF-α has accelerating role in development of type 1 diabetes. Although an immunosupressor function and leading protecting role in T1DM also has been claimed for this pro-inflammatory cytokine. Over-expression of pro-inflammatory and type 1 cytokines (Th1, like IFN-γ) drive insulitis tow...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000155/ https://www.ncbi.nlm.nih.gov/pubmed/24693923 http://dx.doi.org/10.1186/2251-6581-13-46 |