Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications

We have designed a novel non-antibody scaffold protein, termed Adhiron, based on a phytocystatin consensus sequence. The Adhiron scaffold shows high thermal stability (T(m) ca. 101°C), and is expressed well in Escherichia coli. We have determined the X-ray crystal structure of the Adhiron scaffold t...

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Detalles Bibliográficos
Autores principales: Tiede, Christian, Tang, Anna A. S., Deacon, Sarah E., Mandal, Upasana, Nettleship, Joanne E., Owen, Robin L., George, Suja E., Harrison, David J., Owens, Raymond J., Tomlinson, Darren C., McPherson, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000234/
https://www.ncbi.nlm.nih.gov/pubmed/24668773
http://dx.doi.org/10.1093/protein/gzu007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000234/
https://www.ncbi.nlm.nih.gov/pubmed/24668773
http://dx.doi.org/10.1093/protein/gzu007

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