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Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse

Oxysterols are oxidised forms of cholesterol or its precursors. In this study we utilised the cholesterol 24-hydroxylase knockout mouse (Cyp46a1−/−) to study the sterol and oxysterol content of brain. Despite a great reduction in the abundance of 24S-hydroxycholesterol, the dominant metabolite of ch...

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Detalles Bibliográficos
Autores principales: Meljon, Anna, Wang, Yuqin, Griffiths, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000437/
https://www.ncbi.nlm.nih.gov/pubmed/24491562
http://dx.doi.org/10.1016/j.bbrc.2014.01.153