Combined staurosporine and retinoic acid induces differentiation in retinoic acid resistant acute promyelocytic leukemia cell lines

All-trans retinoic acid (ATRA) resistance has been a critical problem in acute promyelocytic leukemia (APL) relapsed patients. In ATRA resistant APL cell lines NB4-R1 and NB4-R2, the combination of staurosporine and ATRA synergized to trigger differentiation accompanied by significantly enhanced pro...

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Detalles Bibliográficos
Autores principales: Ge, Dong-zheng, Sheng, Yan, Cai, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001092/
https://www.ncbi.nlm.nih.gov/pubmed/24769642
http://dx.doi.org/10.1038/srep04821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001092/
https://www.ncbi.nlm.nih.gov/pubmed/24769642
http://dx.doi.org/10.1038/srep04821

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