Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation

In patients who were treated with exogenous BMP-2 to repair bone fractures or defects, the levels of the inflammatory cytokines such as TNF-α and IL-1β in sera are significantly elevated, which may affect the outcome of bone regeneration. Mitogen-activated protein kinase (MAPK) cascades such as extr...

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Detalles Bibliográficos
Autores principales: Huang, R-L, Yuan, Y, Tu, J, Zou, G-M, Li, Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001295/
https://www.ncbi.nlm.nih.gov/pubmed/24743742
http://dx.doi.org/10.1038/cddis.2014.101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001295/
https://www.ncbi.nlm.nih.gov/pubmed/24743742
http://dx.doi.org/10.1038/cddis.2014.101

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