Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

The mitochondrial chaperone mortalin was implicated in Parkinson's disease (PD) because of its reduced levels in the brains of PD patients and disease-associated rare genetic variants that failed to rescue impaired mitochondrial integrity in cellular knockdown models. To uncover the molecular m...

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Detalles Bibliográficos
Autores principales: Burbulla, L F, Fitzgerald, J C, Stegen, K, Westermeier, J, Thost, A-K, Kato, H, Mokranjac, D, Sauerwald, J, Martins, L M, Woitalla, D, Rapaport, D, Riess, O, Proikas-Cezanne, T, Rasse, T M, Krüger, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001296/
https://www.ncbi.nlm.nih.gov/pubmed/24743735
http://dx.doi.org/10.1038/cddis.2014.103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001296/
https://www.ncbi.nlm.nih.gov/pubmed/24743735
http://dx.doi.org/10.1038/cddis.2014.103

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