Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo

Thioredoxin reductase (TrxR) is overpressed in many human tumors and has a key role in regulating intracellular redox balance. Recently, thioredoxin system has emerged as a valuable target for anticancer drug development. Herein we demonstrate that selenocystine (SeC) could enhance auranofin (AF)-in...

Descripción completa

Detalles Bibliográficos
Autores principales: Fan, C, Zheng, W, Fu, X, Li, X, Wong, Y-S, Chen, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001298/
https://www.ncbi.nlm.nih.gov/pubmed/24763048
http://dx.doi.org/10.1038/cddis.2014.132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001298/
https://www.ncbi.nlm.nih.gov/pubmed/24763048
http://dx.doi.org/10.1038/cddis.2014.132

Ejemplares similares