Anticancer compound Oplopantriol A kills cancer cells through inducing ER stress and BH3 proteins Bim and Noxa

Oplopantriol-A (OPT) is a natural polyyne from Oplopanax horridus. We show here that OPT preferentially kills cancer cells and inhibits tumor growth. We demonstrate that OPT-induced cancer cell death is mediated by excessive endoplasmic reticulum (ER) stress. Decreasing the level of ER stress either...

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Detalles Bibliográficos
Autores principales: Jin, H R, Liao, Y, Li, X, Zhang, Z, Zhao, J, Wang, C-Z, Huang, W-H, Li, S-P, Yuan, C-S, Du, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001317/
https://www.ncbi.nlm.nih.gov/pubmed/24763047
http://dx.doi.org/10.1038/cddis.2014.169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001317/
https://www.ncbi.nlm.nih.gov/pubmed/24763047
http://dx.doi.org/10.1038/cddis.2014.169

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