Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

Production of mRNA depends critically on the rate of RNA polymerase II (Pol II) elongation. To dissect Pol II dynamics in mouse ES cells, we inhibited Pol II transcription at either initiation or promoter-proximal pause escape with Triptolide or Flavopiridol, and tracked Pol II kinetically using GRO...

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Detalles Bibliográficos
Autores principales: Jonkers, Iris, Kwak, Hojoong, Lis, John T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001325/
https://www.ncbi.nlm.nih.gov/pubmed/24843027
http://dx.doi.org/10.7554/eLife.02407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001325/
https://www.ncbi.nlm.nih.gov/pubmed/24843027
http://dx.doi.org/10.7554/eLife.02407

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