Aromatic–aromatic interactions between residues in KCa3.1 pore helix and S5 transmembrane segment control the channel gating process

The Ca(2+)-activated potassium channel KCa3.1 is emerging as a therapeutic target for a large variety of health disorders. One distinguishing feature of KCa3.1 is that the channel open probability at saturating Ca(2+) concentrations (Pomax) is low, typically 0.1–0.2 for KCa3.1 wild type. This observ...

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Detalles Bibliográficos
Autores principales: Garneau, Line, Klein, Hélène, Lavoie, Marie-France, Brochiero, Emmanuelle, Parent, Lucie, Sauvé, Rémy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001770/
https://www.ncbi.nlm.nih.gov/pubmed/24470490
http://dx.doi.org/10.1085/jgp.201311097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001770/
https://www.ncbi.nlm.nih.gov/pubmed/24470490
http://dx.doi.org/10.1085/jgp.201311097

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