PLC-mediated PI(4,5)P(2) hydrolysis regulates activation and inactivation of TRPC6/7 channels

Transient receptor potential classical (or canonical) (TRPC)3, TRPC6, and TRPC7 are a subfamily of TRPC channels activated by diacylglycerol (DAG) produced through the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) by phospholipase C (PLC). PI(4,5)P(2) depletion by a heterologousl...

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Detalles Bibliográficos
Autores principales: Itsuki, Kyohei, Imai, Yuko, Hase, Hideharu, Okamura, Yasushi, Inoue, Ryuji, Mori, Masayuki X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001779/
https://www.ncbi.nlm.nih.gov/pubmed/24470487
http://dx.doi.org/10.1085/jgp.201311033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001779/
https://www.ncbi.nlm.nih.gov/pubmed/24470487
http://dx.doi.org/10.1085/jgp.201311033

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