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PLC-mediated PI(4,5)P(2) hydrolysis regulates activation and inactivation of TRPC6/7 channels

Transient receptor potential classical (or canonical) (TRPC)3, TRPC6, and TRPC7 are a subfamily of TRPC channels activated by diacylglycerol (DAG) produced through the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) by phospholipase C (PLC). PI(4,5)P(2) depletion by a heterologousl...

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Detalles Bibliográficos
Autores principales:	Itsuki, Kyohei, Imai, Yuko, Hase, Hideharu, Okamura, Yasushi, Inoue, Ryuji, Mori, Masayuki X.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001779/ https://www.ncbi.nlm.nih.gov/pubmed/24470487 http://dx.doi.org/10.1085/jgp.201311033

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