14‐3‐3‐β and ‐ε contribute to activation of the osmoprotective transcription factor NFAT5 by increasing its protein abundance and its transactivating activity

Having previously found that high NaCl causes rapid exit of 14‐3‐3 isoforms from the nucleus, we used siRNA‐mediated knockdown to test whether 14‐3‐3s contribute to the high NaCl‐induced increase in the activity of the osmoprotective transcription factor NFAT5. We find that, when NaCl is elevated, k...

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Detalles Bibliográficos
Autores principales: Izumi, Yuichiro, Burg, Maurice B., Ferraris, Joan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001879/
https://www.ncbi.nlm.nih.gov/pubmed/24771694
http://dx.doi.org/10.14814/phy2.12000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001879/
https://www.ncbi.nlm.nih.gov/pubmed/24771694
http://dx.doi.org/10.14814/phy2.12000

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