Role of Hepatic and Intestinal P450 Enzymes in the Metabolic Activation of the Colon Carcinogen Azoxymethane in Mice

[Image: see text] P450-mediated bioactivation of azoxymethane (AOM), a colon carcinogen, leads to the formation of DNA adducts, of which O(6)-methylguanine (O(6)-mG) is the most mutagenic and contributes to colon tumorigenesis. To determine whether P450 enzymes of the liver and intestine both contri...

Descripción completa

Detalles Bibliográficos
Autores principales: Megaraj, Vandana, Ding, Xinxin, Fang, Cheng, Kovalchuk, Nataliia, Zhu, Yi, Zhang, Qing-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002058/
https://www.ncbi.nlm.nih.gov/pubmed/24552495
http://dx.doi.org/10.1021/tx4004769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002058/
https://www.ncbi.nlm.nih.gov/pubmed/24552495
http://dx.doi.org/10.1021/tx4004769

Ejemplares similares