Cargando…

Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo

A novel method for the parallel synthesis of peptide-biocargo conjugates was developed that utilizes affinity purification for fast isolation of the conjugates in order to avoid time consuming HPLC purification. The methodology was applied to create two libraries of cell-penetrating peptide (CPP)–PN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deuss, Peter J., Arzumanov, Andrey A., Williams, Donna L., Gait, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2013
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002126/ https://www.ncbi.nlm.nih.gov/pubmed/24105028 http://dx.doi.org/10.1039/c3ob41659c

Ejemplares similares

Improved cell-penetrating peptide–PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle
por: Ivanova, Gabriela D., et al.
Publicado: (2008)

Efficient splicing correction by PNA conjugation to an R(6)-Penetratin delivery peptide
por: Abes, Saïd, et al.
Publicado: (2007)

Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide
por: Abes, Saïd, et al.
Publicado: (2007)

Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells
por: Turner, John J., et al.
Publicado: (2005)

Synthesis and Splice-Redirecting Activity of Branched, Arginine-Rich Peptide Dendrimer Conjugates of Peptide Nucleic Acid Oligonucleotides
por: Saleh, Amer F., et al.
Publicado: (2010)

Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides
por: Turner, John J., et al.
Publicado: (2005)

Cell penetrating peptide conjugates of steric block oligonucleotides()
por: Lebleu, Bernard, et al.
Publicado: (2008)

Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides as Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment
por: Gait, Michael J., et al.
Publicado: (2019)

Automated Flow Synthesis of Peptide–PNA Conjugates
por: Li, Chengxi, et al.
Publicado: (2021)

Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides
por: Tone, Yuichiro, et al.
Publicado: (2021)

The molecular mechanism of photochemical internalization of cell penetrating peptide-cargo-photosensitizer conjugates
por: Ohtsuki, Takashi, et al.
Publicado: (2015)

PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane
por: Goltermann, Lise, et al.
Publicado: (2019)

Synthesis of PNA Oligoether Conjugates
por: Ghidini, Alice, et al.
Publicado: (2014)

Inhibition of Growth and Gene Expression by PNA-peptide Conjugates in Streptococcus pyogenes
por: Patenge, Nadja, et al.
Publicado: (2013)

Diphenylalanine Motif Drives Self‐Assembling in Hybrid PNA‐Peptide Conjugates
por: Diaferia, Carlo, et al.
Publicado: (2021)

Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment
por: Betts, Corinne, et al.
Publicado: (2012)

Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides
por: Järver, Peter, et al.
Publicado: (2015)

Redirecting splicing with bifunctional oligonucleotides
por: Brosseau, Jean-Philippe, et al.
Publicado: (2014)

Cooperative Cellular Uptake and Activity of Octaarginine Antisense Peptide Nucleic Acid (PNA) Conjugates
por: Ghavami, Mahdi, et al.
Publicado: (2019)

Chiral Fibers Formation Upon Assembly of Tetraphenylalanine Peptide Conjugated to a PNA Dimer
por: Mosseri, Andrea, et al.
Publicado: (2022)

Modulation of mdm2 pre-mRNA splicing by 9-aminoacridine-PNA (peptide nucleic acid) conjugates targeting intron-exon junctions
por: Shiraishi, Takehiko, et al.
Publicado: (2010)

Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting
por: Myrhammar, Anders, et al.
Publicado: (2020)

A reversible cell penetrating peptide-cargo linkage allows dissection of cell penetrating peptide- and cargo-dependent effects on internalization and identifies new functionalities of putative endolytic peptides
por: Morris, Daniel P., et al.
Publicado: (2022)

AntimiR-155 Cyclic Peptide–PNA Conjugate: Synthesis, Cellular Uptake, and Biological Activity
por: Soudah, Terese, et al.
Publicado: (2019)

Simultaneous Targeting of Two Master Regulators of Apoptosis with Dual-Action PNA– and DNA–Peptide Conjugates
por: Altrichter, Yannic, et al.
Publicado: (2020)

How Cargo Identity Alters the Uptake of Cell-Penetrating Peptide (CPP)/Cargo Complexes: A Study on the Effect of Net Cargo Charge and Length
por: Hymel, Hannah C., et al.
Publicado: (2022)

Erratum: A reversible cell penetrating peptide-cargo linkage allows dissection of cell penetrating peptide- and cargo-dependent effects on internalization and identifies new functionalities of putative endolytic peptides
por: Frontiers Production Office,
Publicado: (2023)

Corrigendum: A reversible cell penetrating peptide-cargo linkage allows dissection of cell penetrating peptide-and cargo- dependent effects on internalization and identifies new functionalities of putative endolytic peptides
por: Morris, Daniel P., et al.
Publicado: (2023)

A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification
por: Jiang, Ming, et al.
Publicado: (2005)

Gemdimethyl Peptide Nucleic Acids (α/β/γ-gdm-PNA): E/Z-Rotamers Influence the Selectivity in the Formation of Parallel/Antiparallel gdm-PNA:DNA/RNA Duplexes
por: Kulkarni, Pradnya, et al.
Publicado: (2022)

Improving the Endosomal Escape of Cell-Penetrating Peptides and Their Cargos: Strategies and Challenges
por: Erazo-Oliveras, Alfredo, et al.
Publicado: (2012)

Effects of LPS Composition in Escherichia coli on Antibacterial Activity and Bacterial Uptake of Antisense Peptide-PNA Conjugates
por: Goltermann, Lise, et al.
Publicado: (2022)

Tryptophan-PNA gc Conjugates Self-Assemble to Form Fibers
por: Mosseri, Andrea, et al.
Publicado: (2023)

Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice
por: Klein, Arnaud F., et al.
Publicado: (2019)

Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos
por: Kristensen, Mie, et al.
Publicado: (2016)

Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies
por: Li, Hua, et al.
Publicado: (2015)

Cargo self-assembly rescues affinity of cell-penetrating peptides to lipid membranes
por: Weinberger, Andreas, et al.
Publicado: (2017)

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation
por: Ezzat, Kariem, et al.
Publicado: (2011)

A real-time assay for cell-penetrating peptide-mediated delivery of molecular cargos
por: Gentry, Schuyler B., et al.
Publicado: (2021)

Delivery of therapeutic oligonucleotides with cell penetrating peptides()
por: Boisguérin, Prisca, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_mrbalipugroppn3qhbijj7ig5p