Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer

Despite the clinical success of tamoxifen, its resistance remains a major challenge in breast cancer. Here we show that Aurora-A determines tamoxifen sensitivity by regulation of estrogen receptor (ER)α. Ectopic expression of Aurora-A decreases and depletion of Aurora-A enhances tamoxifen sensitivit...

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Detalles Bibliográficos
Autores principales: Zheng, XQ, Guo, JP, Yang, H, Kanai, M, He, LL, Li, YY, Koomen, JM., Minton, S., Gao, M, Ren, XB, Coppola, D, Cheng, JQ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002670/
https://www.ncbi.nlm.nih.gov/pubmed/24166501
http://dx.doi.org/10.1038/onc.2013.444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002670/
https://www.ncbi.nlm.nih.gov/pubmed/24166501
http://dx.doi.org/10.1038/onc.2013.444

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