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A high-throughput screening system for G-protein-coupled receptors using β-lactamase enzyme complementation technology
AIM: To establish a system for monitoring the activation of G-protein-coupled receptors (GPCRs) using β-lactamase enzyme fragment complementation (EFC) technology. METHODS: Two inactive β-lactamase deletion fragments, bla(a) and bla(b), were fused to β-arrestin and GPCR, respectively. A stable cell...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002942/ https://www.ncbi.nlm.nih.gov/pubmed/21102483 http://dx.doi.org/10.1038/aps.2010.154 |