State-dependent block of Orai3 TM1 and TM3 cysteine mutants: Insights into 2-APB activation

After endoplasmic reticulum (ER) Ca(2+) store depletion, Orai channels in the plasma membrane (PM) are activated directly by ER-resident stromal interacting molecule (STIM) proteins to form the Ca(2+)-selective Ca(2+) release-activated Ca(2+) (CRAC) channel. Of the three human Orai channel homologue...

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Detalles Bibliográficos
Autores principales: Amcheslavsky, Anna, Safrina, Olga, Cahalan, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003185/
https://www.ncbi.nlm.nih.gov/pubmed/24733836
http://dx.doi.org/10.1085/jgp.201411171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003185/
https://www.ncbi.nlm.nih.gov/pubmed/24733836
http://dx.doi.org/10.1085/jgp.201411171

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