Sensitivity of MLL-rearranged AML cells to all-trans retinoic acid is associated with the level of H3K4me2 in the RARα promoter region

All-trans retinoic acid (ATRA) is well established as differentiation therapy for acute promyelocytic leukemia (APL) in which the PML–RARα (promyelocytic leukemia-retinoic acid receptor α) fusion protein causes blockade of the retinoic acid (RA) pathway; however, in types of acute myeloid leukemia (...

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Detalles Bibliográficos
Autores principales: Sakamoto, K, Imamura, T, Yano, M, Yoshida, H, Fujiki, A, Hirashima, Y, Hosoi, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003419/
https://www.ncbi.nlm.nih.gov/pubmed/24769646
http://dx.doi.org/10.1038/bcj.2014.25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003419/
https://www.ncbi.nlm.nih.gov/pubmed/24769646
http://dx.doi.org/10.1038/bcj.2014.25

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