APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition

Long INterspersed Element-1 (LINE-1 or L1) retrotransposition poses a mutagenic threat to human genomes. Human cells have therefore evolved strategies to regulate L1 retrotransposition. The APOBEC3 (A3) gene family consists of seven enzymes that catalyze deamination of cytidine nucleotides to uridin...

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Detalles Bibliográficos
Autores principales: Richardson, Sandra R, Narvaiza, Iñigo, Planegger, Randy A, Weitzman, Matthew D, Moran, John V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Genomics and Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003774/
https://www.ncbi.nlm.nih.gov/pubmed/24843014
http://dx.doi.org/10.7554/eLife.02008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003774/
https://www.ncbi.nlm.nih.gov/pubmed/24843014
http://dx.doi.org/10.7554/eLife.02008

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