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Genome-scale metabolic network reconstruction of Saccharopolyspora spinosa for Spinosad Production improvement
BACKGROUND: Spinosad is a macrolide antibiotic produced by Saccharopolyspora spinosa with aerobic fermentation. However, the wild strain has a low productivity. In this article, a computational guided engineering approach was adopted in order to improve the yield of spinosad in S. spinosa. RESULTS:...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003821/ https://www.ncbi.nlm.nih.gov/pubmed/24628959 http://dx.doi.org/10.1186/1475-2859-13-41 |