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Metabolic flux responses to genetic modification for shikimic acid production by Bacillus subtilis strains

BACKGROUND: Shikimic acid (SA) is a key chiral starting molecule for the synthesis of the neuramidase inhibitor GS4104 against viral influenza. Microbial production of SA has been extensively investigated in Escherichia coli, and to a less extent in Bacillus subtilis. However, metabolic flux of the...

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Detalles Bibliográficos
Autores principales:	Liu, Dong-Feng, Ai, Guo-Min, Zheng, Qing-Xiang, Liu, Chang, Jiang, Cheng-Ying, Liu, Li-Xia, Zhang, Bo, Liu, Yi-Ming, Yang, Chen, Liu, Shuang-Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003833/ https://www.ncbi.nlm.nih.gov/pubmed/24628944 http://dx.doi.org/10.1186/1475-2859-13-40

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