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Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway

BACKGROUND: Previous work in our laboratory demonstrated that hyperoxia suppressed the expression of vascular endothelial growth factor (VEGF) by the embryonic lung, leading to increased epithelial cell apoptosis and failure of explant airway growth and branching that was rescued by the addition of...

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Detalles Bibliográficos
Autores principales: Esquibies, Americo E, Karihaloo, Anil, Quaggin, Susan E, Bazzy-Asaad, Alia, Cantley, Lloyd G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004166/
https://www.ncbi.nlm.nih.gov/pubmed/24641672
http://dx.doi.org/10.1186/1465-9921-15-32