Detection of Protein–Protein Interactions by Proximity-Driven S(N)Ar Reactions of Lysine-Linked Fluorophores

[Image: see text] Critical protein–protein interactions are ubiquitous in biology. To provide a new method to detect these interactions, we designed and synthesized fluorinated bromopyronins as molecular probes. These electrophilic compounds rapidly react with amines via a S(N)Ar mechanism to form m...

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Detalles Bibliográficos
Autores principales: Hymel, David, Woydziak, Zachary R., Peterson, Blake R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004224/
https://www.ncbi.nlm.nih.gov/pubmed/24660775
http://dx.doi.org/10.1021/ja501253b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004224/
https://www.ncbi.nlm.nih.gov/pubmed/24660775
http://dx.doi.org/10.1021/ja501253b

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