Metal-Dependent Conformational Activation Explains Highly Promutagenic Replication across O6-Methylguanine by Human DNA Polymerase β

[Image: see text] Human DNA polymerase β (polβ) inserts, albeit slowly, T opposite the carcinogenic lesion O6-methylguanine (O6MeG) ∼30-fold more frequently than C. To gain insight into this promutagenic process, we solved four ternary structures of polβ with an incoming dCTP or dTTP analogue base-p...

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Detalles Bibliográficos
Autores principales: Koag, Myong-Chul, Lee, Seongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004240/
https://www.ncbi.nlm.nih.gov/pubmed/24694247
http://dx.doi.org/10.1021/ja500172d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004240/
https://www.ncbi.nlm.nih.gov/pubmed/24694247
http://dx.doi.org/10.1021/ja500172d

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