Directed Evolution of Multivalent Glycopeptides Tightly Recognized by HIV Antibody 2G12

[Image: see text] Herein, we report a method for in vitro selection of multivalent glycopeptides, combining mRNA display with incorporation of unnatural amino acids and “click” chemistry. We have demonstrated the use of this method to design potential glycopeptide vaccines against HIV. From librarie...

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Detalles Bibliográficos
Autores principales: Horiya, Satoru, Bailey, Jennifer K., Temme, J. Sebastian, Guillen Schlippe, Yollete V., Krauss, Isaac J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004241/
https://www.ncbi.nlm.nih.gov/pubmed/24645849
http://dx.doi.org/10.1021/ja500678v

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004241/
https://www.ncbi.nlm.nih.gov/pubmed/24645849
http://dx.doi.org/10.1021/ja500678v

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