Cargando…
Directed Evolution of Multivalent Glycopeptides Tightly Recognized by HIV Antibody 2G12
[Image: see text] Herein, we report a method for in vitro selection of multivalent glycopeptides, combining mRNA display with incorporation of unnatural amino acids and “click” chemistry. We have demonstrated the use of this method to design potential glycopeptide vaccines against HIV. From librarie...
Autores principales: | Horiya, Satoru, Bailey, Jennifer K., Temme, J. Sebastian, Guillen Schlippe, Yollete V., Krauss, Isaac J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004241/ https://www.ncbi.nlm.nih.gov/pubmed/24645849 http://dx.doi.org/10.1021/ja500678v |
Ejemplares similares
-
High Temperature
SELMA: Evolution of DNA-Supported
Oligomannose Clusters Which Are Tightly Recognized by HIV bnAb 2G12
por: Temme, J. Sebastian, et al.
Publicado: (2014) -
In Vitro Selection of Highly Modified
Cyclic Peptides That Act as Tight Binding Inhibitors
por: Guillen Schlippe, Yollete V., et al.
Publicado: (2012) -
Oligomannose Glycopeptide Conjugates Elicit Antibodies
Targeting the Glycan Core Rather than Its Extremities
por: Nguyen, Dung N., et al.
Publicado: (2019) -
On‐Chip Neo‐Glycopeptide Synthesis for Multivalent Glycan Presentation
por: Mende, Marco, et al.
Publicado: (2020) -
Probing Multivalent Carbohydrate-Protein Interactions With On-Chip Synthesized Glycopeptides Using Different Functionalized Surfaces
por: Tsouka, Alexandra, et al.
Publicado: (2021)