Gold(III) Macrocycles: Nucleotide-Specific Unconventional Catalytic Inhibitors of Human Topoisomerase I

[Image: see text] Topoisomerase IB (Top1) is a key eukaryotic nuclear enzyme that regulates the topology of DNA during replication and gene transcription. Anticancer drugs that block Top1 are either well-characterized interfacial poisons or lesser-known catalytic inhibitor compounds. Here we describ...

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Detalles Bibliográficos
Autores principales: Akerman, Kate J., Fagenson, Alexander M., Cyril, Vidusha, Taylor, Michael, Muller, Mark T., Akerman, Matthew P., Munro, Orde Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004252/
https://www.ncbi.nlm.nih.gov/pubmed/24694294
http://dx.doi.org/10.1021/ja412350f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004252/
https://www.ncbi.nlm.nih.gov/pubmed/24694294
http://dx.doi.org/10.1021/ja412350f

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