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Substrate Rescue of DNA Polymerase β Containing a Catastrophic L22P Mutation
[Image: see text] DNA polymerase (pol) β is a multidomain enzyme with two enzymatic activities that plays a central role in the overlapping base excision repair and single-strand break repair pathways. The high frequency of pol β variants identified in tumor-derived tissues suggests a possible role...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004254/ https://www.ncbi.nlm.nih.gov/pubmed/24655288 http://dx.doi.org/10.1021/bi5001855 |