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Substrate Rescue of DNA Polymerase β Containing a Catastrophic L22P Mutation

[Image: see text] DNA polymerase (pol) β is a multidomain enzyme with two enzymatic activities that plays a central role in the overlapping base excision repair and single-strand break repair pathways. The high frequency of pol β variants identified in tumor-derived tissues suggests a possible role...

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Detalles Bibliográficos
Autores principales:	Kirby, Thomas W., DeRose, Eugene F., Beard, William A., Shock, David D., Wilson, Samuel H., London, Robert E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004254/ https://www.ncbi.nlm.nih.gov/pubmed/24655288 http://dx.doi.org/10.1021/bi5001855

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