Acceleration of an Aromatic Claisen Rearrangement via a Designed Spiroligozyme Catalyst that Mimics the Ketosteroid Isomerase Catalytic Dyad

[Image: see text] A series of hydrogen-bonding catalysts have been designed for the aromatic Claisen rearrangement of a 1,1-dimethylallyl coumarin. These catalysts were designed as mimics of the two-point hydrogen-bonding interaction present in ketosteroid isomerase that has been proposed to stabili...

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Detalles Bibliográficos
Autores principales: Parker, Matthew F. L., Osuna, Sílvia, Bollot, Guillaume, Vaddypally, Shivaiah, Zdilla, Michael J., Houk, K. N., Schafmeister, Christian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004270/
https://www.ncbi.nlm.nih.gov/pubmed/24456160
http://dx.doi.org/10.1021/ja409214c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004270/
https://www.ncbi.nlm.nih.gov/pubmed/24456160
http://dx.doi.org/10.1021/ja409214c

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