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Lung Remodeling in a Mouse Model of Asthma Involves a Balance between TGF-β1 and BMP-7
A key event in chronic allergic asthma is the TGF-β-induced activation of fibroblasts into α-SMA-positive myofibroblasts which synthesize type-I collagen. In the present study we investigated the effect of the anti-fibrotic molecule BMP-7 in asthma. Balb/c mice were immunized i.p. with ovalbumin in...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004563/ https://www.ncbi.nlm.nih.gov/pubmed/24781156 http://dx.doi.org/10.1371/journal.pone.0095959 |