Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress–induced cell death during the unfolded protein response

Endoplasmic reticulum (ER) protein misfolding activates the unfolded protein response (UPR) to help cells cope with ER stress. If ER homeostasis is not restored, UPR promotes cell death. The mechanisms of UPR-mediated cell death are poorly understood. The PKR-like endoplasmic reticulum kinase (PERK)...

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Detalles Bibliográficos
Autores principales: Hiramatsu, Nobuhiko, Messah, Carissa, Han, Jaeseok, LaVail, Matthew M., Kaufman, Randal J., Lin, Jonathan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004591/
https://www.ncbi.nlm.nih.gov/pubmed/24623724
http://dx.doi.org/10.1091/mbc.E13-11-0664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004591/
https://www.ncbi.nlm.nih.gov/pubmed/24623724
http://dx.doi.org/10.1091/mbc.E13-11-0664

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