Sustained CD4(+) T cell-driven lymphopenia without a compensatory IL-7/IL-15 response among high-grade glioma patients treated with radiation and temozolomide

Prolonged lymphopenia correlating with decreased survival commonly occurs among glioma patients undergoing radiation therapy (RT) and temozolomide (TMZ) treatment. To better understand the pathophysiology of this phenomenon, we prospectively monitored serum cytokine levels and lymphocyte subsets in...

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Detalles Bibliográficos
Autores principales: Ellsworth, Susannah, Balmanoukian, Ani, Kos, Ferdynand, Nirschl, Christopher J, Nirschl, Thomas R, Grossman, Stuart A, Luznik, Leo, Drake, Charles G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004618/
https://www.ncbi.nlm.nih.gov/pubmed/24790790
http://dx.doi.org/10.4161/onci.27357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004618/
https://www.ncbi.nlm.nih.gov/pubmed/24790790
http://dx.doi.org/10.4161/onci.27357

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