Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

Fully phosphorothioate antisense oligonucleotides (ASOs) with locked nucleic acids (LNAs) improve target affinity, RNase H activation and stability. LNA modified ASOs can cause hepatotoxicity, and this risk is currently not fully understood. In vitro cytotoxicity screens have not been reliable predi...

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Detalles Bibliográficos
Autores principales: Burdick, Andrew D., Sciabola, Simone, Mantena, Srinivasa R., Hollingshead, Brett D., Stanton, Robert, Warneke, James A., Zeng, Ming, Martsen, Elena, Medvedev, Alexander, Makarov, Sergei S., Reed, Lori A., Davis, John W., Whiteley, Laurence O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005641/
https://www.ncbi.nlm.nih.gov/pubmed/24550163
http://dx.doi.org/10.1093/nar/gku142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005641/
https://www.ncbi.nlm.nih.gov/pubmed/24550163
http://dx.doi.org/10.1093/nar/gku142

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