Cargando…

Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

Fully phosphorothioate antisense oligonucleotides (ASOs) with locked nucleic acids (LNAs) improve target affinity, RNase H activation and stability. LNA modified ASOs can cause hepatotoxicity, and this risk is currently not fully understood. In vitro cytotoxicity screens have not been reliable predi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burdick, Andrew D., Sciabola, Simone, Mantena, Srinivasa R., Hollingshead, Brett D., Stanton, Robert, Warneke, James A., Zeng, Ming, Martsen, Elena, Medvedev, Alexander, Makarov, Sergei S., Reed, Lori A., Davis, John W., Whiteley, Laurence O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005641/ https://www.ncbi.nlm.nih.gov/pubmed/24550163 http://dx.doi.org/10.1093/nar/gku142

Ejemplares similares

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts
por: Burel, Sebastien A., et al.
Publicado: (2016)

Targeting 3′ and 5′ untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression
por: Li, Yanjie, et al.
Publicado: (2021)

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
por: Østergaard, Michael E., et al.
Publicado: (2013)

MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice
por: Cogoi, Susanna, et al.
Publicado: (2013)

Characterization of plastid psbT sense and antisense RNAs
por: Zghidi-Abouzid, Ouafa, et al.
Publicado: (2011)

Highly efficient silencing of microRNA by heteroduplex oligonucleotides
por: Yoshioka, Kotaro, et al.
Publicado: (2019)

Sense and antisense transcription are associated with distinct chromatin architectures across genes
por: Murray, Struan C., et al.
Publicado: (2015)

Natural antisense transcripts are significantly involved in regulation of drought stress in maize
por: Xu, Jie, et al.
Publicado: (2017)

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression
por: Zaghloul, Eman M., et al.
Publicado: (2017)

Antisense transcriptional interference mediates condition-specific gene repression in budding yeast
por: Nevers, Alicia, et al.
Publicado: (2018)

Antisense-mediated repression of SAGA-dependent genes involves the HIR histone chaperone
por: Soudet, Julien, et al.
Publicado: (2022)

Splicing of a non-coding antisense transcript controls LEF1 gene expression
por: Beltran, Manuel, et al.
Publicado: (2015)

Genome-wide relationship between R-loop formation and antisense transcription in Escherichia coli
por: Raghunathan, Nalini, et al.
Publicado: (2018)

S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum
por: André, Gaëlle, et al.
Publicado: (2008)

Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast
por: Castelnuovo, Manuele, et al.
Publicado: (2014)

Antisense ribosomal siRNAs inhibit RNA polymerase I-directed transcription in C. elegans
por: Liao, Shimiao, et al.
Publicado: (2021)

The fate of notch-1 transcript is linked to cell cycle dynamics by activity of a natural antisense transcript
por: Vujovic, Filip, et al.
Publicado: (2021)

A pre-initiation complex at the 3′-end of genes drives antisense transcription independent of divergent sense transcription
por: Murray, Struan C., et al.
Publicado: (2012)

Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress
por: Servant, Géraldine, et al.
Publicado: (2012)

ZWC complex-mediated SPT5 phosphorylation suppresses divergent antisense RNA transcription at active gene promoters
por: Park, Kihyun, et al.
Publicado: (2022)

A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies
por: Sun, Jingnan, et al.
Publicado: (2014)

Upregulation of SPS100 gene expression by an antisense RNA via a switch of mRNA isoforms with different stabilities
por: Bunina, Daria, et al.
Publicado: (2017)

Temporal analyses reveal a pivotal role for sense and antisense enhancer RNAs in coordinate immunoglobulin lambda locus activation
por: Gao, Zeqian, et al.
Publicado: (2023)

Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription
por: Sansó, Miriam, et al.
Publicado: (2020)

The genomic region of the 3′ untranslated region (3′UTR) of PHO84, rather than the antisense RNA, promotes gene repression
por: Hegazy, Youssef A, et al.
Publicado: (2023)

The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering
por: Hendrix, Jelle, et al.
Publicado: (2011)

Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer
por: Cruickshanks, Hazel A., et al.
Publicado: (2013)

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation
por: Marinello, Jessica, et al.
Publicado: (2013)

OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency
por: Bernard, Laure D, et al.
Publicado: (2022)

CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene
por: Langmann, Thomas, et al.
Publicado: (2008)

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
por: Swayze, Eric E., et al.
Publicado: (2007)

Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones
por: Popova, Liudmila V, et al.
Publicado: (2021)

Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides
por: Kasuya, Takeshi, et al.
Publicado: (2016)

The transcription factor Sox5 modulates Sox10 function during melanocyte development
por: Stolt, C. Claus, et al.
Publicado: (2008)

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex
por: Thiaville, Michelle M., et al.
Publicado: (2008)

The CaMV transactivator/viroplasmin interferes with RDR6-dependent trans-acting and secondary siRNA pathways in Arabidopsis
por: Shivaprasad, Padubidri V., et al.
Publicado: (2008)

Expanded binding specificity of the human histone chaperone NASP
por: Wang, Huanyu, et al.
Publicado: (2008)

Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRγ
por: Song, Guisheng, et al.
Publicado: (2008)

Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation
por: Roque, Alicia, et al.
Publicado: (2008)

Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk
por: Spatuzza, Carmen, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_7m9uimv16682hj8ukrsc30n31k