The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stress

In quiescent fibroblasts, the expression levels of cytosolic enzymes for thymidine triphosphate (dTTP) synthesis are down-regulated, causing a marked reduction in the dTTP pool. In this study, we provide evidence that mitochondrial thymidylate synthesis via thymidine kinase 2 (TK2) is a limiting fac...

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Detalles Bibliográficos
Autores principales: Lee, Ming-Hsiang, Wang, Liya, Chang, Zee-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005647/
https://www.ncbi.nlm.nih.gov/pubmed/24561807
http://dx.doi.org/10.1093/nar/gku152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005647/
https://www.ncbi.nlm.nih.gov/pubmed/24561807
http://dx.doi.org/10.1093/nar/gku152

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