Reversible Top1 cleavage complexes are stabilized strand-specifically at the ribosomal replication fork barrier and contribute to ribosomal DNA stability

Various topological constraints at the ribosomal DNA (rDNA) locus impose an extra challenge for transcription and DNA replication, generating constant torsional DNA stress. The topoisomerase Top1 is known to release such torsion by single-strand nicking and re-ligation in a process involving transie...

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Detalles Bibliográficos
Autores principales: Krawczyk, Claudia, Dion, Vincent, Schär, Primo, Fritsch, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005688/
https://www.ncbi.nlm.nih.gov/pubmed/24574527
http://dx.doi.org/10.1093/nar/gku148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005688/
https://www.ncbi.nlm.nih.gov/pubmed/24574527
http://dx.doi.org/10.1093/nar/gku148

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