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Massive parallel-sequencing-based hydroxyl radical probing of RNA accessibility

Hydroxyl Radical Footprinting (HRF) is a tried-and-tested method for analysis of the tertiary structure of RNA and for identification of protein footprints on RNA. The hydroxyl radical reaction breaks accessible parts of the RNA backbone, thereby allowing ribose accessibility to be determined by det...

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Detalles Bibliográficos
Autores principales: Kielpinski, Lukasz Jan, Vinther, Jeppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005689/
https://www.ncbi.nlm.nih.gov/pubmed/24569351
http://dx.doi.org/10.1093/nar/gku167