Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors

Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter. Signalling through mammalian target of rapamycin complex 1 (mTORC1...

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Detalles Bibliográficos
Autores principales: Liu, Rui, Iadevaia, Valentina, Averous, Julien, Taylor, Peter M., Zhang, Ze, Proud, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005692/
https://www.ncbi.nlm.nih.gov/pubmed/24526220
http://dx.doi.org/10.1093/nar/gku130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005692/
https://www.ncbi.nlm.nih.gov/pubmed/24526220
http://dx.doi.org/10.1093/nar/gku130

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