A Human Blood-Brain Barrier Transcytosis Assay Reveals Antibody Transcytosis Influenced by pH-Dependent Receptor Binding

We have adapted an in vitro model of the human blood-brain barrier, the immortalized human cerebral microvascular endothelial cells (hCMEC/D3), to quantitatively measure protein transcytosis. After validating the receptor-mediated transport using transferrin, the system was used to measure transcyto...

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Detalles Bibliográficos
Autores principales: Sade, Hadassah, Baumgartner, Claudia, Hugenmatter, Adrian, Moessner, Ekkehard, Freskgård, Per-Ola, Niewoehner, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005765/
https://www.ncbi.nlm.nih.gov/pubmed/24788759
http://dx.doi.org/10.1371/journal.pone.0096340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005765/
https://www.ncbi.nlm.nih.gov/pubmed/24788759
http://dx.doi.org/10.1371/journal.pone.0096340

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