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Fatty acids increase neuronal hypertrophy of Pten knockdown neurons
Phosphatase and tensin homolog (Pten) catalyzes the reverse reaction of PI3K by dephosphorylating PIP3 to PIP2. This negatively regulates downstream Akt/mTOR/S6 signaling resulting in decreased cellular growth and proliferation. Co-injection of a lentivirus knocking Pten down with a control lentivir...
Autores principales: | Fricano, Catherine J., DeSpenza, Tyrone, Frazel, Paul W., Li, Meijie, O'Malley, A. James, Westbrook, Gary L., Luikart, Bryan W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006057/ https://www.ncbi.nlm.nih.gov/pubmed/24795563 http://dx.doi.org/10.3389/fnmol.2014.00030 |
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