Cargando…

Loss of the TNFα function inhibits Wnt/β-catenin signaling, exacerbates obesity development in adolescent spontaneous obese mice

Tumor necrosis factor alpha (TNFα) is an adipokine involved in the regulation of cell differentiation and lipid metabolism, but its specific role has not been clearly understood. We validated a hypothesis that loss of TNFα function would inhibit Wnt/β-catenin signaling and accelerate adipogenesis in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gong, Maolei, Liu, Chuanguo, Zhang, Liang, Zhang, Hongbin, Pan, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006126/ https://www.ncbi.nlm.nih.gov/pubmed/24522555 http://dx.doi.org/10.1007/s11010-014-1987-5

Ejemplares similares

Wnt/β-Catenin Signaling and Obesity
por: Chen, Na, et al.
Publicado: (2018)

Small molecule inhibitors of WNT/β-catenin signaling block IL-1β- and TNFα-induced cartilage degradation
por: Landman, Ellie BM, et al.
Publicado: (2013)

Serum TNF-α, GTH and MDA of high-fat diet-induced obesity and obesity resistant rats
por: Wu, Peixian, et al.
Publicado: (2016)

TNFα drives mitochondrial stress in POMC neurons in obesity
por: Yi, Chun-Xia, et al.
Publicado: (2017)

Obesity Increases Airway Hyperresponsiveness via the TNF-α Pathway and Treating Obesity Induces Recovery
por: Kim, Joo Young, et al.
Publicado: (2015)

TNF-α promotes the malignant transformation of intestinal stem cells through the NF-κB and Wnt/β-catenin signaling pathways
por: Zhao, Xiaopeng, et al.
Publicado: (2020)

Targeting Wnt/β-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF
por: Wang, Hao, et al.
Publicado: (2022)

Evaluation of TNF-α and IL-6 Levels in Obese and Non-obese Diabetics: Pre- and Postinsulin Effects
por: Goyal, Rajeev, et al.
Publicado: (2012)

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss
por: Choi, Bu Young
Publicado: (2020)

The small molecule indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity
por: Choi, O M, et al.
Publicado: (2014)

The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wnt/β-Catenin Signaling Activation in Podocytes
por: Liu, Bao-li, et al.
Publicado: (2015)

Evaluation of tumor necrosis factor-α (TNF-α) levels in plasma and their correlation with periodontal status in obese and non-obese subjects
por: Khanna, Suruchi, et al.
Publicado: (2010)

Relationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity
por: Ramon-Krauel, Marta, et al.
Publicado: (2021)

Antagonism of Cell Adhesion by an α-Catenin Mutant, and of the Wnt-signaling Pathway by α-Catenin in Xenopus Embryos
por: Sehgal, Ravinder N.M., et al.
Publicado: (1997)

α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes
por: Choi, Seung H., et al.
Publicado: (2013)

PHF8 promotes osteogenic differentiation of BMSCs in old rat with osteoporosis by regulating Wnt/β-catenin pathway
por: Pan, Feng, et al.
Publicado: (2022)

Up-regulation of syncytin-1 contributes to TNF-α-enhanced fusion between OSCC and HUVECs partly via Wnt/β-catenin-dependent pathway
por: Yan, Ting-Lin, et al.
Publicado: (2017)

Loss of DSTYK activates Wnt/β-catenin signaling and glycolysis in lung adenocarcinoma
por: Zhong, Chenxi, et al.
Publicado: (2021)

Unaltered TNF-α production by macrophages and monocytes in diet-induced obesity in the rat
por: Bedoui, Sammy, et al.
Publicado: (2005)

Lycopene supplementation reduces TNF-α via RAGE in the kidney of obese rats
por: Pierine, D T, et al.
Publicado: (2014)

Proinflammatory cytokines IL-6 and TNF-α and the development of inflammation in obese subjects
por: Popko, K, et al.
Publicado: (2010)

Evaluation of Level of TNF-α among Obese Patients with and without Chronic Periodontitis
por: Fathima, Kamal Hameed, et al.
Publicado: (2022)

Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production
por: Ip, Blanche, et al.
Publicado: (2015)

Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway
por: Liu, Bing, et al.
Publicado: (2021)

Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
por: Chen, Jin-Ran, et al.
Publicado: (2010)

Loss of TGF-β or Wnt5a results in an increase in Wnt/β-catenin activity and redirects mammary tumour phenotype
por: Roarty, Kevin, et al.
Publicado: (2009)

WNKs in Wnt/β-catenin signaling
por: Serysheva, Ekatherina, et al.
Publicado: (2014)

Targeting the Wnt/β-catenin signaling pathway in cancer
por: Zhang, Ya, et al.
Publicado: (2020)

Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers
por: Kern, Lara, et al.
Publicado: (2018)

Effect of Aerobic Exercise on Serum Concentration of Apelin, TNFα and Insulin in Obese Women
por: Sheibani, Shahin, et al.
Publicado: (2012)

Modulating PKCα Activity to Target Wnt/β-Catenin Signaling in Colon Cancer
por: Dupasquier, Sébastien, et al.
Publicado: (2019)

Osteoblastic glucocorticoid signaling exacerbates high-fat-diet- induced bone loss and obesity
por: Kim, Sarah, et al.
Publicado: (2021)

Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis
por: Huo, J, et al.
Publicado: (2016)

The inhibition of enterocyte proliferation by lithocholic acid exacerbates necrotizing enterocolitis through downregulating the Wnt/β‐catenin signalling pathway
por: Feng, Zhoushan, et al.
Publicado: (2022)

Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway
por: Wang, Zuoyun, et al.
Publicado: (2020)

MicroRNA-200a suppresses the Wnt/β-catenin signaling pathway by interacting with β-catenin
por: SU, JUAN, et al.
Publicado: (2011)

Obesity-induced inflammation exacerbates clonal hematopoiesis
por: Pasupuleti, Santhosh Kumar, et al.
Publicado: (2023)

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
por: Lin, Chung-Ming, et al.
Publicado: (2017)

The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats
por: Decara, Juan, et al.
Publicado: (2018)

Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways
por: Bouaziz, Wafa, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_qsc9tounoeu4ea6a8h78rd4pel