Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP Production

Parathyroid hormone-related protein (PTHrP) can be secreted from cells and interact with its receptor, the Type 1 PTH/PTHrP Receptor (PTHR1) in an autocrine, paracrine or endocrine fashion. PTHrP can also remain inside cells and be transported into the nucleus, where its functions are unclear, altho...

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Detalles Bibliográficos
Autores principales: Boras-Granic, Kata, Dann, Pamela, VanHouten, Joshua, Karaplis, Andrew, Wysolmerski, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006745/
https://www.ncbi.nlm.nih.gov/pubmed/24785493
http://dx.doi.org/10.1371/journal.pone.0090418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006745/
https://www.ncbi.nlm.nih.gov/pubmed/24785493
http://dx.doi.org/10.1371/journal.pone.0090418

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