Up-Regulating CYP3A4 Expression in C3A Cells by Transfection with a Novel Chimeric Regulator of hPXR-p53-AD

Most hepatoma cell lines lack proper expression and induction of CYP3A4 enzyme, which limits their use for predicting drug metabolism and toxicity. Nuclear receptor pregnane X receptor (PXR) has been well recognized for its critical role in regulating expression of CYP3A4 gene. However, its physiolo...

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Detalles Bibliográficos
Autores principales: Chen, Feng, Rao, Xiao-Hui, Yang, Jin-Lian, Pan, Ming-Xing, Gao, Yi, Li, Zhen-Lin, Li, Yang, Zhu, You-Fu, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006776/
https://www.ncbi.nlm.nih.gov/pubmed/24788541
http://dx.doi.org/10.1371/journal.pone.0095752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006776/
https://www.ncbi.nlm.nih.gov/pubmed/24788541
http://dx.doi.org/10.1371/journal.pone.0095752

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