Cargando…

Up-Regulating CYP3A4 Expression in C3A Cells by Transfection with a Novel Chimeric Regulator of hPXR-p53-AD

Most hepatoma cell lines lack proper expression and induction of CYP3A4 enzyme, which limits their use for predicting drug metabolism and toxicity. Nuclear receptor pregnane X receptor (PXR) has been well recognized for its critical role in regulating expression of CYP3A4 gene. However, its physiolo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Feng, Rao, Xiao-Hui, Yang, Jin-Lian, Pan, Ming-Xing, Gao, Yi, Li, Zhen-Lin, Li, Yang, Zhu, You-Fu, Wang, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006776/ https://www.ncbi.nlm.nih.gov/pubmed/24788541 http://dx.doi.org/10.1371/journal.pone.0095752

Ejemplares similares

Toxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid
por: Brewer, Christopher Trent, et al.
Publicado: (2020)

Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha
por: Conde, Isabel, et al.
Publicado: (2008)

Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR
por: Duan, Ya-bin, et al.
Publicado: (2020)

A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile
por: Bailey, Ian, et al.
Publicado: (2011)

Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice
por: McMillan, JoEllyn M., et al.
Publicado: (2018)

The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids
por: Smutny, Tomas, et al.
Publicado: (2020)

PXR: a center of transcriptional regulation in cancer
por: Xing, Yaqi, et al.
Publicado: (2020)

Transcriptional Regulation of CYP3A4/2B6/2C9 Mediated via Nuclear Receptor PXR by Helicid and Its Metabolites
por: Chen, Qun, et al.
Publicado: (2015)

PXR-Mediated Upregulation of CYP3A Expression by Herb Compound Praeruptorin C from Peucedanum praeruptorum Dunn
por: Huang, Ling, et al.
Publicado: (2013)

PXR interaction with p53: a meeting of two masters
por: Robbins, D, et al.
Publicado: (2016)

Regulation of CAR and PXR Expression in Health and Disease
por: Daujat-Chavanieu, Martine, et al.
Publicado: (2020)

Erratum to “PXR-Mediated Upregulation of CYP3A Expression by Herb Compound Praeruptorin C from Peucedanum praeruptorum Dunn”
por: Huang, Ling, et al.
Publicado: (2014)

No Correlation of hsa-miR-148a with Expression of PXR or CYP3A4 in Human Livers from Chinese Han Population
por: Wei, Zhiyun, et al.
Publicado: (2013)

Transcriptional Regulation of Mouse PXR Gene: An Interplay of Transregulatory Factors
por: Kumari, Sangeeta, et al.
Publicado: (2012)

Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes
por: Korhonova, Martina, et al.
Publicado: (2015)

Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway
por: Zhou, Xiaoqiao, et al.
Publicado: (2016)

Up-Regulation of CYP2C19 Expression by BuChang NaoXinTong via PXR Activation in HepG2 Cells
por: Sun, Hong, et al.
Publicado: (2016)

miR-148a-mediated estrogen-induced cholestasis in intrahepatic cholestasis of pregnancy: Role of PXR/MRP3
por: Rao, Zhou-Zhou, et al.
Publicado: (2017)

Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity
por: Wang, Cheng, et al.
Publicado: (2018)

Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5
por: Collins, Joseph M., et al.
Publicado: (2022)

Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis
por: Guo, Hanze, et al.
Publicado: (2021)

Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning
por: Rigalli, Juan Pablo, et al.
Publicado: (2021)

Antioxidant, Anticancer, and PXR-Dependent CYP(3)A(4) Attributes of Schweinfurthia papilionacea (Burm.f.) Boiss., Tricholepis glaberrima DC. and Viola stocksii Boiss
por: Shahbaz, Amir, et al.
Publicado: (2022)

Probiotics mixture reinforces barrier function to ameliorate necrotizing enterocolitis by regulating PXR-JNK pathway
por: Zhao, Xiuhao, et al.
Publicado: (2021)

The role of pregnane X receptor (PXR) in substance metabolism
por: Lv, Ye, et al.
Publicado: (2022)

Enhancement of CYP3A4 Activity in Hep G2 Cells by Lentiviral Transfection of Hepatocyte Nuclear Factor-1 Alpha
por: Chiang, Tsai-Shin, et al.
Publicado: (2014)

PXR is a target of (-)-epicatechin in skeletal muscle
por: Ortiz-Flores, Miguel, et al.
Publicado: (2020)

PXR as a mediator of herb–drug interaction
por: Hogle, Brett C., et al.
Publicado: (2017)

Chinese herbal component, Praeruptorin E, enhances anti-asthma efficacy and prevents toxicity of aminophylline by targeting the NF-κB/PXR/CYP3A4 pathway
por: Xu, Ronghua, et al.
Publicado: (2022)

Lycium Barbarum Polysaccharides and Wolfberry Juice Prevent DEHP-Induced Hepatotoxicity via PXR-Regulated Detoxification Pathway
por: Liu, Huan, et al.
Publicado: (2021)

Chimeric RNA TNNI2-ACTA1-V1 Regulates Cell Proliferation by Regulating the Expression of NCOA3
por: Liu, Dongyu, et al.
Publicado: (2022)

Rifaximin, a pregnane X receptor (PXR) activator regulates apoptosis in a murine model of breast cancer
por: Gautam, Swetlana, et al.
Publicado: (2018)

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation
por: Bwayi, Monicah N, et al.
Publicado: (2022)

Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway
por: He, Liuqin, et al.
Publicado: (2017)

Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium Ferulate
por: Gao, Lichen, et al.
Publicado: (2013)

Rapid maturation of the hepatic cell line Huh7 via CDK inhibition for PXR dependent CYP450 metabolism and induction
por: Bulutoglu, Beyza, et al.
Publicado: (2019)

A Functional Polymorphism in the 3'-UTR of PXR Interacts with Smoking to Increase Lung Cancer Risk in Southern and Eastern Chinese Smoker
por: Zhang, Lisha, et al.
Publicado: (2014)

Role of CTCF in Regulating SLC45A3-ELK4 Chimeric RNA
por: Qin, Fujun, et al.
Publicado: (2016)

Regulation of CYP3A genes by glucocorticoids in human lung cells
por: Roberts, Jessica K, et al.
Publicado: (2013)

MD Investigation on the Interaction between Carbamazepine and Two CYP Isoforms, CYP3A4 and CYP3A5
por: Liu, Shuhui, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_o9si7eteik42qe60hm9tnk7j9m