Immunosurveillance of senescent cancer cells by natural killer cells

We recently dissected how senescent tumors can trigger complementing signaling pathways that mobilize natural killer (NK) cells to eliminate malignant cells. In addition to cell-intrinsic effects on proliferation, senescence induces the production of chemokine (C-C motif) ligand 2 (CCL2), which recr...

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Detalles Bibliográficos
Autores principales: Iannello, Alexandre, Raulet, David H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006855/
https://www.ncbi.nlm.nih.gov/pubmed/24800169
http://dx.doi.org/10.4161/onci.27616
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author Iannello, Alexandre
Raulet, David H
author_facet Iannello, Alexandre
Raulet, David H
author_sort Iannello, Alexandre
collection PubMed
description We recently dissected how senescent tumors can trigger complementing signaling pathways that mobilize natural killer (NK) cells to eliminate malignant cells. In addition to cell-intrinsic effects on proliferation, senescence induces the production of chemokine (C-C motif) ligand 2 (CCL2), which recruits NK cells to mediate direct tumoricidal effects. Hence, senescence activates a cancer cell-extrinsic oncosuppression program.
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spelling pubmed-40068552014-05-05 Immunosurveillance of senescent cancer cells by natural killer cells Iannello, Alexandre Raulet, David H Oncoimmunology Author's View We recently dissected how senescent tumors can trigger complementing signaling pathways that mobilize natural killer (NK) cells to eliminate malignant cells. In addition to cell-intrinsic effects on proliferation, senescence induces the production of chemokine (C-C motif) ligand 2 (CCL2), which recruits NK cells to mediate direct tumoricidal effects. Hence, senescence activates a cancer cell-extrinsic oncosuppression program. Landes Bioscience 2014-01-06 /pmc/articles/PMC4006855/ /pubmed/24800169 http://dx.doi.org/10.4161/onci.27616 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Iannello, Alexandre
Raulet, David H
Immunosurveillance of senescent cancer cells by natural killer cells
title Immunosurveillance of senescent cancer cells by natural killer cells
title_full Immunosurveillance of senescent cancer cells by natural killer cells
title_fullStr Immunosurveillance of senescent cancer cells by natural killer cells
title_full_unstemmed Immunosurveillance of senescent cancer cells by natural killer cells
title_short Immunosurveillance of senescent cancer cells by natural killer cells
title_sort immunosurveillance of senescent cancer cells by natural killer cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006855/
https://www.ncbi.nlm.nih.gov/pubmed/24800169
http://dx.doi.org/10.4161/onci.27616
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