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Push and release: TLR9 activation plus STAT3 blockade for systemic antitumor immunity

Proper immunostimulation (“push”) and immune checkpoint blockade (“release”) are both critical for the efficacy of anticancer immunotherapy. We have recently shown that activating Toll-like receptor 9 (TLR9) while specifically blocking signal transducer and activator of transcription 3 (STAT3) in le...

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Detalles Bibliográficos
Autores principales: Kortylewski, Marcin, Kuo, Ya-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006856/
https://www.ncbi.nlm.nih.gov/pubmed/24800162
http://dx.doi.org/10.4161/onci.27441