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The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses
Upon antigenic stimulation, naïve CD8(+) T cells divert their bioenergetic metabolism from oxidative phosphorylation to aerobic glycolysis. This drives CD8(+) T cells to differentiate into short-lived effectors, impairing the establishment of immunological memory. The pharmacological inhibition of g...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006859/ https://www.ncbi.nlm.nih.gov/pubmed/24800166 http://dx.doi.org/10.4161/onci.27573 |