The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses

Upon antigenic stimulation, naïve CD8(+) T cells divert their bioenergetic metabolism from oxidative phosphorylation to aerobic glycolysis. This drives CD8(+) T cells to differentiate into short-lived effectors, impairing the establishment of immunological memory. The pharmacological inhibition of g...

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Detalles Bibliográficos
Autores principales: Sukumar, Madhusudhanan, Gattinoni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006859/
https://www.ncbi.nlm.nih.gov/pubmed/24800166
http://dx.doi.org/10.4161/onci.27573
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author Sukumar, Madhusudhanan
Gattinoni, Luca
author_facet Sukumar, Madhusudhanan
Gattinoni, Luca
author_sort Sukumar, Madhusudhanan
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description Upon antigenic stimulation, naïve CD8(+) T cells divert their bioenergetic metabolism from oxidative phosphorylation to aerobic glycolysis. This drives CD8(+) T cells to differentiate into short-lived effectors, impairing the establishment of immunological memory. The pharmacological inhibition of glycolysis with 2-deoxyglucose enhances the generation of memory CD8(+) T cells and thus improves their immunotherapeutic potential against cancer.
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spelling pubmed-40068592014-05-05 The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses Sukumar, Madhusudhanan Gattinoni, Luca Oncoimmunology Author's View Upon antigenic stimulation, naïve CD8(+) T cells divert their bioenergetic metabolism from oxidative phosphorylation to aerobic glycolysis. This drives CD8(+) T cells to differentiate into short-lived effectors, impairing the establishment of immunological memory. The pharmacological inhibition of glycolysis with 2-deoxyglucose enhances the generation of memory CD8(+) T cells and thus improves their immunotherapeutic potential against cancer. Landes Bioscience 2014-01-03 /pmc/articles/PMC4006859/ /pubmed/24800166 http://dx.doi.org/10.4161/onci.27573 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Sukumar, Madhusudhanan
Gattinoni, Luca
The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses
title The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses
title_full The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses
title_fullStr The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses
title_full_unstemmed The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses
title_short The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses
title_sort short and sweet of t-cell therapy: restraining glycolysis enhances the formation of immunological memory and antitumor immune responses
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006859/
https://www.ncbi.nlm.nih.gov/pubmed/24800166
http://dx.doi.org/10.4161/onci.27573
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